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KMID : 0371319730150050031
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Journal of the Korean Surgical Society
1973 Volume.15 No. 5 p.31 ~ p.36
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Studies to detect the mechanism of prolonged survival of enhanced rat renal allograft
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Abstract
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Both active and passive immunological enhancement has shown promise as a means of specificc immunosuppression but precise administration of antigen or specific antibody is necessary.
Renal transplantation was performed between inbred rats after pretreatment with 0. 5 mg. i. v. soluble splenic antigen from the donor strain, LBNFI rat, for active enhancement, and after the manual perfusion of LBNF, donor kidney with 0.5 mg. F(ab´)2 fragment and daily i.v. injection for 5 times for passive enhancement.
To detect the possible mechanism of prolonged survival of renal allograft, the 10 long survived (average survival times is 70 days) kidney recipients were selected and received the following immunological studies.
Skin graft test as a secondary antigen challenge showed first set type rejection frcm 9 to 14 days. Histological findings of the biopsy specimens of enhanced transplanted kidney showed a mild degree of chronic rejection reaction in all rats. Lymphocytotoxic antibody test showed high titer which was comparable to control rats for 2 weeks after transplantation, thereafter gradually decrease to normal range. The Simonsen´s local GVH reactivities of spleen cells of long survived rats were markedly increased at the time of transplantation and then decreased to normal range at the time of kidney biopsy.
Therefore the author believed the mechanism of prologed survival of rat renal allograft would be rather enhancement or enhancement and partial tolerance than tolerance alone.
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KEYWORD
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